Wikipedia -WSS

Wikipedia

author：focus 2025-10-02 20:59:19 - browse：43

Adam's take main illustration — Molly Ferguson/STAT

Annovis Bio had my biotech bull%^&! meter running red after it made a late change to the design of a Phase 3 study in Parkinson’s disease. But then I got an extraordinary explanation from CEO Maria Maccecchini. Now, I’m less worried about data spin because, by her own admission, the odds that the study succeeds, post endpoint change, are a lot lower.

Results from the completed Parkinson’s study, which is investigating Annovis’ drug called buntanetap, are well past due because of what the company has described as ongoing “data cleaning efforts.” The delay was announced on Jan. 24. Two weeks later, on Feb. 6, the primary efficacy endpoint of the study was changed, according to an update posted to the U.S. government’s clinical trials database.

Red flag, I thought, until I emailed Maccecchini, asking for an explanation. In response, she told me Annovis made the key endpoint change in August, based on a recommendation from officials at the Food and Drug Administration after the agency had reviewed data from an interim analysis of the study. It took the company another six months to update the study design in the ClinicalTrials.gov database, for reasons she did not explain.

Get unlimited access to award-winning journalism and exclusive events.

Subscribe Log In

Previous article： How to save PrEP access — and even expand it
Next article： Why hospitals are withdrawing from US News rankings

WSS

Listen: Wegovy in the brain & pivotal Alzheimer's data

The strange history of BMI, the body mass index

UnitedHealth wins $3.3 billion takeover of Amedisys

As digital health tech proliferates, a new institute aims to cut through hype

Doctors find melanoma drugs effective against rare brain cancer

GOP hopefuls to address prominent, controversial group questioning what's taught in schools

hotspot

Wikipedia

hotspot

23andMe had bad news about my health. I wish a person had delivered it

EHR maker NextGen Healthcare to pay $31M to resolve fraud claims

Activists slam private health insurers over coverage restrictions

STAT Virtual Event: The State of Biosimilars: What to Watch

Continuity nursing helped my family in our darkest PICU moments

In early work, researchers turn to CRISPR to treat Alzheimer's

New Eli Lilly Alzheimer’s data poses Medicare coverage conundrum

ADA: All diabetes patients should be screened for liver condition

Affirmative action in medical school literally saved lives

GOP hopefuls to address prominent, controversial group questioning what's taught in schools

entertainment

In early work, researchers turn to CRISPR to treat Alzheimer's

A public scorecard can help hold safety

Sanofi seeks simpler, safer CRISPR sickle cell cure

Supreme Court rules employers must be more accommodating of religious observance

In early work, researchers turn to CRISPR to treat Alzheimer's

Supreme Court strikes down Biden student loan forgiveness program

hotspot

leisure time

Wikipedia

Wikipedia