knowledge -WSS

knowledge

author：explore 2025-10-02 07:45:06 - browse：1468

On Tuesday, Google DeepMind and Isomorphic Labs announced a significant progress update on the next iteration of AlphaFold, the deep learning model that in 2020 cracked the problem of predicting a protein’s structure from its amino acid sequence, leapfrogging other approaches in computational biology.

Now, the companies say they have developed the model to predict not just standalone protein structures, but what proteins look like in combination with several classes of molecules, including small molecules and nucleic acids — capabilities that are key for drug development.

“We really needed to make progress on protein-ligand binding and co-folding of ligands with proteins in order to help us design more effective drugs,” said Demis Hassabis, CEO of both DeepMind and Isomorphic Labs, which spun out in 2021 with the goal of applying deep learning approaches to drug discovery. The updated model can also predict protein structures after they’ve been modified. “Basically the new AlphaFold can cope with all of these different things, which is pretty amazing.”

Get unlimited access to award-winning journalism and exclusive events.

Subscribe Log In

Previous article： Medicare proposal to cover medical devices draws a mixed reaction
Next article： Dramatically reducing cancer deaths requires the PASTEUR Act

WSS

Readout Newsletter: Bristol, Sangamo, Gilead, and more

WuXi out of biotech trade group, U.S. and China relations to blame

The drug industry sees a key ally in the Senate prevail

OTC birth control: A brief history of over the counter pill design

Readout LOUD podcast: ALS dilemma, first MASH drug, and more

John Green on his newest strategy for fighting tuberculosis

focus

knowledge

knowledge

Drug repurposing or repositioning? The language matters

Nearly two

Hepatitis C has a cure — but many Americans still lack access to it

What Mike Pence has said that could be used in a Donald Trump trial

Biden outlines 'new path' to provide student loan relief after Supreme Court rejection

Microsoft strikes partnership with Duke Health to advance health AI

Virginia high school admissions case could be legal follow

Change Healthcare outage fallout shows need for new oversight

Dobbs anniversary: the lost opportunity of abortion as health care

OTC birth control: A brief history of over the counter pill design

hotspot

OTC birth control: A brief history of over the counter pill design

2 US Navy sailors arrested for allegedly spying for China

FDA advisers back CAR

Male and female sex labels in research insufficient, scientists say

Trump drops motion seeking removal of DA probing efforts to overturn 2020 election in Georgia

WuXi out of biotech trade group, U.S. and China relations to blame

leisure time

leisure time

focus

leisure time