hotspot -WSS

hotspot

author：fashion 2025-09-30 22:09:11 - browse：67746

BiTE Bridge — Illustration of a BiTE, Amgen's bispecific antibodies Amgen

In cancer immunotherapy these days, technology is advancing so fast that 2017’s buzzy new treatment may soon be passe: Only 18 months after approval of the first CAR-T, pharmaceutical companies and biotechs are already talking about next-generation cancer therapy.

Called bispecific antibodies, they’re being developed by some two dozen companies large and small, with a version cleverly branded as BiTEs already constituting 60 percent of Amgen’s oncology pipeline. The appeal: Bispecifics make the immune system kill tumor cells like first-gen immunotherapy, but, unlike the weeks it takes to laboriously manufacture CAR-Ts, they can start being infused almost as quickly as an oncologist can write a prescription.

“We’re very bullish” on BiTEs, said Dr. David Reese, head of R&D at Amgen, which has the only cancer-targeting bispecific approved for clinical use in the U.S. and 14 more in development, including for multiple myeloma, small cell lung cancer, glioblastoma, and other solid tumors. “We can generate a BiTE against any tumor antigen we want to go after.”

Unlock this article by subscribing to STAT+ and enjoy your first 30 days free!

GET STARTED Log In

Previous article： Continuity nursing helped my family in our darkest PICU moments
Next article： Judge in Trump's classified documents case questions use of out

WSS

How to improve immunocompromised access to mAb treatments

Sanofi strikes deal with Novavax, boosting the vaccine maker

Flash flood warnings continue for parts of Missouri, Illinois

Software glitch causes Tandem insulin pump to shutdown, FDA warns

Software glitch causes Tandem insulin pump to shutdown, FDA warns

First recipient of genetically engineered pig kidney has died

focus

hotspot

leisure time

Biden outlines 'new path' to provide student loan relief after Supreme Court rejection

Medicare says breakthrough device reimbursement rule to come by summer

Medical leaders decry Supreme Court decision on affirmative action

A fugitive mob suspect in Greece is betrayed by his passion for hometown Naples soccer champions

The cancer drug shortage isn’t new — and neither are the solutions

Judge in Trump's classified documents case questions use of out

Walensky prepares to leave CDC — and Congress — behind

Doctors push to include dialysis machines in emergency stockpile

In age of alternative facts, a scholarly course on calling out crap

Judge in Trump's classified documents case questions use of out

hotspot

Study: People of West African ancestry at greater risk of cardiac amyloidosis

CDC wastewater surveillance dashboard to track bird flu hotspots

It shouldn't be easy to buy synthetic DNA to recreate a deadly virus

H5N1 communication has been strictly for the birds

Election results set back Medicaid expansion plans

Feed a cold, starve a fever? Here’s what science says

hotspot

focus

Wikipedia

hotspot