fashion -WSS

fashion

author：explore 2025-09-30 20:20:14 - browse：97531

The bacterium A. baylyi was engineered to detect a common cancer mutation. Courtesy of Josephine Wright

Dan Worthley, a gastroenterologist and cancer scientist at Colonoscopy Clinic in Brisbane, Australia, does thousands of colonoscopies a year, seeking and destroying precancerous polyps. It’s a practically surefire way to prevent colorectal cancer, but an unpleasant experience for patients. The future, Worthley hopes, will be much less onerous — and he’s developing a technology that, if it works one day, might make the experience more of a piece of cake.

Or, rather, a cup of yogurt — containing engineered bacteria that can detect and deliver a treatment for colorectal polyps or cancer. Worthley and colleagues at the University of California, San Diego, and the University of Adelaide published results in Science on Thursday that show they are one step closer to that far-off dream. In their paper, the researchers show a proof-of-concept engineered bacterium that can detect cancer DNA in the guts of mice and react to it by turning on certain cellular circuitry.

“I think it’s really cool. It introduces a new concept for how you can use cells as a sensor for something happening inside other cells,” said Mikhail Shapiro, a chemical and medical engineer at the California Institute of Technology who did not work on the study. “That can flip a switch inside those cells. In this case, it’s used for diagnostic output, but in principle it could be used for other things.”

Unlock this article by subscribing to STAT+ and enjoy your first 30 days free!

GET STARTED Log In

Previous article： Medicare details structure of new drug price negotiation program
Next article： Cancer drug shortages should be causing more outrage

WSS

Affirmative action in medical school literally saved lives

Group opposing PBM reform sets lobbying record

Malaria cases in Florida and Texas: Here’s what you need to know

At Orexo, a ‘turning point’ for everything but digital health

Virginia high school admissions case could be legal follow

ARCH Venture Partners tops STAT's 2023 biotech VC rankings

focus

fashion

Wikipedia

Medicare details structure of new drug price negotiation program

Rescued Australian man who was adrift 3 months in Pacific with dog 'grateful' to be alive

After affirmative action ruling, medical educators look to 'holistic review'

WHO calls for emergency meeting on new China virus, as cases spread

Medical records are filled with copy

EHR maker NextGen Healthcare to pay $31M to resolve fraud claims

Continuity nursing helped my family in our darkest PICU moments

BioMarin wins approval for gene therapy to treat hemophilia A

State Dept. review finds Biden bears some blame for Afghanistan failures

A public scorecard can help hold safety

hotspot

ChatGPT in medicine: STAT answers readers' burning questions

ARCH Venture Partners tops STAT's 2023 biotech VC rankings

Medical leaders decry Supreme Court decision on affirmative action

In early work, researchers turn to CRISPR to treat Alzheimer's

Sanofi seeks simpler, safer CRISPR sickle cell cure

WHO calls for emergency meeting on new China virus, as cases spread

explore

hotspot

hotspot

focus