entertainment -WSS

entertainment

author：entertainment 2025-10-01 18:07:27 - browse：43857

Adam's take main illustration — Molly Ferguson/STAT

This week, I address pushback I received on my Novartis-MorphoSys column. But first, a preview of the expected readout from Gritstone Bio’s neoantigen cancer vaccine study.

A looming test for neoantigen cancer vaccines

Before the end of the quarter, Gritstone Bio will release preliminary results from a randomized, Phase 2 clinical trial investigating a personalized therapeutic cancer vaccine in microsatellite-stable colon cancer, a type of “immunologically cold” tumor that is resistant to immunotherapies like PD-1/PD-L1 inhibitors.

The Gritstone vaccine is designed to train a patient’s own T cells to recognize and kill cancer cells by targeting mutated cancer proteins, called neoantigens, that are unique to a patient’s own tumor. It’s a relatively new approach for cancer vaccines — made possible by powerful and relatively inexpensive genomic sequencing of tumors – that is intended to overcome all the previous failures in the field. Gritstone’s effort is also similar to one being used by Moderna and Merck that has reported encouraging results in melanoma — and is now being investigated in a Phase 3 study.

Get unlimited access to award-winning journalism and exclusive events.

Subscribe Log In

Previous article： Supreme Court strikes down use of affirmative action
Next article： What is STAT's opinion section for?

WSS

McConnell had minor fall 2 weeks ago, uses wheelchair periodically to get around: Sources

Trader Joe's recalls 10K cases of broccoli cheddar soup over potential foreign material

Biden to sign 'historic' executive order on how US military handles sexual assault cases

Biden announces an advanced cancer research initiative

McConnell had minor fall 2 weeks ago, uses wheelchair periodically to get around: Sources

Cancer diagnosis changes perspective doctor, former hospital CEO

hotspot

entertainment

A looming test for neoantigen cancer vaccines

explore

Drug repurposing or repositioning? The language matters

Marc Tessier

Activists slam private health insurers over coverage restrictions

Publishing genetic code of viruses could cause disaster

Novavax promises a turnaround & Lilly roils the obesity market

After decades in use, heart stents finally beat placebo

Activists slam private health insurers over coverage restrictions

Weight loss drugs should be covered by insurers, AMA says

State Dept. review finds Biden bears some blame for Afghanistan failures

Timeline: Special counsel's probe into Trump's handling of classified documents

focus

'Hero' Louisville officer shot in head at mass shooting discharged over 3 months later

Hospitals, health systems can help patients avoid medical debt

First transplant of an entire human eye performed

Weight loss drugs should be covered by insurers, AMA says

American Airlines has a tentative contract deal with its pilots. Southwest is still negotiating

Readout Newsletter: Ozempic panic wanes, Legend x Novartis, etc.

knowledge

leisure time

explore

focus