leisure time -WSS

leisure time

author：Wikipedia 2025-10-02 00:51:58 - browse：81577

Two people stare at a keyhole in a human head in between them, as the short-haired person on the left holds a key — first opinion coverage from STAT — Adobe

In many ways, psychiatry is still flying blind. People experiencing mental health conditions are prescribed various drugs until one (or a combination) finally works — a painful process that can take years. As a psychiatrist and neuroscientist, I became increasingly impatient and frustrated with this ineffective way of treating patients. This guided the core question behind my research: Can biology explain how people with the same psychiatric disorder respond differently to the same treatment?

Since I first began exploring this question more than a decade ago, mental illness has become a global epidemic. Despite significant efforts, progress in psychiatric drug development has remained disappointingly slow. There have been a few notable approvals in recent years, and a renewal of interest by Big Pharma, following a retreat from psychiatric research in the mid to late 2000s. But the landscape remains predominantly marked by failures and a dry drug development pipeline. Approved drugs follow the same pattern of prescribing via guesswork, with most patients not responding to a given drug. This cycle of trial-and-error drug development producing trial-and-error treatment arises from a simple source: We have not systematized a process for learning from our failures and successes.

Related: A ‘renaissance in neuroscience’ could deliver a fresh crop of psychiatric medicines

For example, take depression: While the rise of selective serotonin reuptake inhibitors (SSRIs) in the 1980s and 1990s seemed to provide a solution, seminal studies in the 2000s exposed fundamental limitations of our treatment options. Antidepressants are widely prescribed, but their efficacy relative to placebo is modest.

Get unlimited access to award-winning journalism and exclusive events.

Subscribe Log In

Previous article： 23andMe had bad news about my health. I wish a person had delivered it
Next article： Grail spinoff by Illumina should end disastrous merger attempt

WSS

Asa Hutchinson previews new plan to reform federal law enforcement if elected in 2024

House passes resolution saying Israel isn't a 'racist or apartheid state'

Hospitals owned by private equity see complications spike 25%

Why you get paid to donate plasma but not blood

Why health care costs have stayed mostly flat since 2010

UK homeowners get some respite as inflation falls by more than anticipated to a 15

hotspot

leisure time

Related: A ‘renaissance in neuroscience’ could deliver a fresh crop of psychiatric medicines

Wikipedia

23andMe had bad news about my health. I wish a person had delivered it

US soldier in North Korean custody after crossing DMZ line

Virginia high school admissions case could be legal follow

BridgeBio heart drug succeeds in pivotal study

Novavax promises a turnaround & Lilly roils the obesity market

Why you get paid to donate plasma but not blood

ChatGPT in medicine: STAT answers readers' burning questions

ER docs worry over extreme heat as a 'mass casualty event'

FDA approval of Sarepta Duchenne genetic therapy gives me hope

Idaho college killings: Prosecutors dispute DNA could have been planted at murder scene

focus

Albert Bourla of Pfizer: worst biopharma CEO of 2023

Three trends to watch in biotech in 2024

Medicare drug price negotiation hasn't dried up venture capital

DeSantis says Trump could've 'come out more forcefully' during Jan. 6

More hospitals are billing patients as online messages surge

Prime Medicine, Myeloid Therapeutics clash over genome

explore

hotspot

knowledge

hotspot