knowledge -WSS

knowledge

author：entertainment 2025-09-30 18:08:20 - browse：16564

Enticed by the immense market opened by GLP-1 weight loss drugs Wegovy and Zepbound, a handful of biotech companies are trying to develop next-generation, longer-lasting therapies based on a very different approach: RNA interference.

This Nobel Prize-winning science works by degrading the biological blueprints that RNA use to make proteins — without the genetic instructions, the troublesome proteins are never made and the gene is essentially muted.

If the companies succeed, it would be a significant shift in the obesity treatment revolution, away from weekly drugs targeting hormones to medications that could be given much less frequently — twice a year or even less — and pinpoint genetic contributors to weight.

STAT+ Exclusive Story

Already have an account? Log in

This article is exclusive to STAT+ subscribers

Unlock this article — plus daily coverage and analysis of the biotech sector — by subscribing to STAT+.

Already have an account? Log in

Monthly

$39

Totals $468 per year

$39/month Get Started

Totals $468 per year

Starter

$30

for 3 months, then $39/month

$30 for 3 months Get Started

Then $39/month

Annual

$399

Save 15%

$399/year Get Started

Save 15%

11+ Users

Custom

Savings start at 25%!

Request A Quote Request A Quote

Savings start at 25%!

2-10 Users

$300

Annually per user

$300/year Get Started

$300 Annually per user

View All Plans

Get unlimited access to award-winning journalism and exclusive events.

Subscribe Log In

Previous article： Drug repurposing or repositioning? The language matters
Next article： Asahi Kasei to buy Calliditas, picking up kidney disease drug

WSS

Decentralized clinical trials need collaboration to achieve wider use

Achieving telehealth equity for people with hearing loss

Tulsa Race Massacre survivors and attorneys respond to dismissal of lawsuit

The world needs the new pandemic treaty

Dozens of beaches across Northeast closed for swimming due to high levels of bacteria in water

Biden’s NIH nominee is languishing in Congress

explore

knowledge

This article is exclusive to STAT+ subscribers

Unlock this article — plus daily coverage and analysis of the biotech sector — by subscribing to STAT+.

hotspot

The Supreme Court will review a ruling striking down a domestic violence federal gun ban

U.S. death rates show how politics are affecting public health

Medical leaders decry Supreme Court decision on affirmative action

Parents surprise family after baby discharged from NICU after 170 days

Activists slam private health insurers over coverage restrictions

The aspartame in Diet Coke probably isn’t giving you cancer

Virginia high school admissions case could be legal follow

Accuser who called Kevin Spacey 'vile sexual predator' admits he joked about incident

Medical records are filled with copy

See Ryan Reynolds, Hugh Jackman suited up in 1st look at 'Deadpool 3': Photo

entertainment

New research sheds light on how often breast cancer is overdiagnosed

ACA's risk program benefits Blue Cross Blue Shield insurers

Dozens of beaches across Northeast closed for swimming due to high levels of bacteria in water

Pandemic and All Hazards Preparedness Act needs lean update

See Ryan Reynolds, Hugh Jackman suited up in 1st look at 'Deadpool 3': Photo

J&J reports mixed data on next

explore

focus

leisure time

focus