Wikipedia -WSS

Wikipedia

author：focus 2025-09-30 18:17:20 - browse：2211

Representative fluorescent multiplex immunohistochemistry colorful staining of healthy human colon. -- cancer coverage from STAT — Staining reveals different immune cells in a healthy human colon. Courtesy Olivia Newton-John Cancer Research institute

Within the linings of our guts, immune cells patrol like sentries on a castle wall. These cells, called intraepithelial T lymphocytes, are constantly probing the cells of the gut barrier for signs of disease, killing any cells that appear suspect due to infections or cancer mutations.

A new paper published in Science Immunologyon Friday suggests that a subtype of T cells called gamma-delta T cells may be key to that process — and that a protein known as TCF-1 is central to controlling their actions. The work, led by Australian researchers, helps unlock the long underappreciated role of these cells in cancer defense and could open new directions for developing immunotherapies for colorectal cancer, immunologists said.

Gamma-delta T cells have been “largely understudied” compared to their immune counterparts, alpha-beta T cells, said Ana Carrizosa Anderson, a cancer researcher at Harvard University who did not work on the study. “This study certainly helps cement the role of gamma-delta T cells in colon malignancy,” she said. “I think it provides a foundation for building understanding of some basic biology or some therapeutic approaches.”

Get unlimited access to award-winning journalism and exclusive events.

Subscribe Log In

Previous article： Trump demands the U.S. pay no more for drugs than other countries … again
Next article： Chris Christie meets with Zelenskyy during Ukraine trip

WSS

Flint parents haunted by uncertainty, fears of lead poisoning

How to ethically and practically extend health care to all

Elizabeth Holmes on track for early release from her 11

2 officers injured in shooting in Orlando, police say

Medicare slashes safety net hospital payments by nearly $1 billion

Biden launches a new push to limit health care costs

hotspot

Wikipedia

knowledge

Trump demands the U.S. pay no more for drugs than other countries … again

What to know about OceanGate, the company behind the missing Titanic submersible

Wildfire smoke exposes gaps in outdoor worker protections

Group behind ProMed defends move to subscription

New air purifier tech could be key to improving indoor air quality

Leqembi, other new Alzheimer’s drugs require better biomarkers

Medicare details structure of new drug price negotiation program

N.Y. state detects polio case, first in the U.S. since 2013

Sports medicine is finally prioritizing gender equality

Late stage cancers on the rise after pandemic delayed screenings

leisure time

Bulgari apologizes to China for listing Taiwan as a country after online backlash

Study links childhood stress with decline in older age

How to ethically and practically extend health care to all

Biotech startup Celsius cuts 75% of staff ahead of first trial start

NIH fellows want a pay raise. Will that mean less money for grants?

Lecanemab for Alzheimer's is coming. Is the health system ready?

hotspot

leisure time

focus

hotspot