Wikipedia -WSS

Wikipedia

author：fashion 2025-10-01 13:58:46 - browse：5548

The ability of cancer cells to move and spread depends on actin-rich core structures such as the podosomes (yellow) shown here in melanoma cells. Cell nuclei (blue), actin (red), and an actin regulator (green) are also shown. — Metastatic melanoma cells Julio C. Valencia,/NCI Center for Cancer Research

Nearly four decades after its first conception, the first TIL therapy, an immunotherapy that harvests cancer-fighting immune cells from the patient’s own body, received accelerated approval from the Food and Drug Administration for advanced melanoma. The therapy, called Amtagvi or lifileucel from Iovance, is the first cell therapy approved for a solid tumor.

“It’s so exciting and gratifying,” said Allison Betof Warner, a cell therapy researcher and physician at Stanford University who has worked on Amtagvi. “This is a game-changing moment for our field. We’ve seen huge success of cellular therapy for hematologic malignancies, and we’ve yet to capitalize on that for solid tumors. This is hopefully the first of many to come.”

In a Phase 2 clinical trial, titled C-144-01, 153 patients who had already been on a median of three prior lines of therapy received lifileucel, and 31% of them responded to therapy. “These are in very late line patients. They’ve exhausted every standard care option,” Betof Warner said. “The most promising part of this therapy for me is that 42% of patients who responded were still responding for 18 months or longer. It’s truly incredible.”

Get unlimited access to award-winning journalism and exclusive events.

Subscribe Log In

Previous article： Novavax promises a turnaround & Lilly roils the obesity market
Next article： Campaign finance charge dropped from case against Sam Bankman

WSS

J&J to buy cancer drug developer Ambrx Biopharma

Japan raises alarm over China's military, Russia ties and Taiwan tensions in new defense paper

Japan raises alarm over China's military, Russia ties and Taiwan tensions in new defense paper

9 mass shootings over the weekend rock US cities, leaving 5 dead, 56 injured

Goldman Sachs launches $650M fund for life science investments

J&J to buy cancer drug developer Ambrx Biopharma

explore

Wikipedia

focus

Alkermes shareholders re

Many immigrants are left out of maternal health programs

Anesthesiologist group: stop taking Ozempic before surgery

Russian and Belarusian players banned from a women's tennis tournament in Prague

The cancer drug shortage isn’t new — and neither are the solutions

GSK Flovent asthma inhalers replaced by authorized generics

George Santos makes 1st court appearance after pleading not guilty to 13 counts

Russian and Belarusian players banned from a women's tennis tournament in Prague

Activists slam private health insurers over coverage restrictions

J&J to buy cancer drug developer Ambrx Biopharma

knowledge

At JPM, Bristol Myers Squibb CEO tries to soothe investor nerves

Young Chinese opt out of the rat race and pressures at home to pursue global nomad lifestyle

Adidas to release second batch of Yeezy sneakers after breakup with Ye

Young Chinese opt out of the rat race and pressures at home to pursue global nomad lifestyle

AdventHealth escalates lawsuit against insurance vendor Multiplan

Many immigrants are left out of maternal health programs

hotspot

Wikipedia

Wikipedia

entertainment