Wikipedia -WSS

Wikipedia

author：explore 2025-10-01 14:20:19 - browse：97279

Adam's take main illustration — Molly Ferguson/STAT

The Food and Drug Administration should halt Cassava Sciences’ ongoing clinical trials in Alzheimer’s disease. That, and other thoughts on the fallout from the City University of New York investigation that raised serious doubts about the science underpinning the company’s experimental drug simufilam.

Patient safety is paramount to the FDA, so stopping Cassava’s two Phase 3 studies is the ethically correct thing to do.The FDA has the power to place clinical holds on experimental drugs when there’s evidence of an unacceptable safety risk to study participants. Simufilam doesn’t appear to be toxic. It’s not causing dangerous side effects. But study participants can also be harmed when they volunteer for a clinical trial based on false or misleading information about a drug’s potential efficacy.

The CUNY committee charged with investigating Cassava’s principal scientific collaborator, the neuroscientist Hoau-Yan Wang, could not definitively prove that Wang faked simufilam data, but that’s only because he refused to turn over original data and primary research records that the committee had requested to examine. Wang also claimed that boxes of research records relevant to the investigation were thrown away. The investigative report was first made public last week in the journal Science.

Get unlimited access to award-winning journalism and exclusive events.

Subscribe Log In

Previous article： Walensky prepares to leave CDC — and Congress — behind
Next article： Readout Newsletter: Vertex, Biogen's Aduhelm, and Bristol updates

knowledge

WSS

Calls for Trump's election interference trial to be televised part of long debate

Judge in Trump's Jan. 6 case gives attorneys 2 weeks to propose trial date

SAMSHA loosens regulations on methadone treatment centers

Even great ERs can’t make up for American health disparities

Cognito secures funding to test medical device for Alzheimer's

Pediatricians' group reaffirms support for gender

focus

Wikipedia

leisure time

Alkermes shareholders re

The real point of Kenneth Smith’s execution by nitrogen gas

In Memoriam: Notable people who died in 2023

Time to name cancers by genetics, not organ of origin, expert says

George Santos makes 1st court appearance after pleading not guilty to 13 counts

Calls for Trump's election interference trial to be televised part of long debate

Wildfire smoke exposes gaps in outdoor worker protections

US Marines prepare to be put on commercial ships to deter Iranian harassment in Strait of Hormuz

ChatGPT in medicine: STAT answers readers' burning questions

Rivals hope for voter 'fatigue' as Trump's woes mount but base stays loyal: ANALYSIS

focus

California Joshua trees severely burned in massive wildfire

'Cuddling' is just what the doctor ordered for a 200

The lessons of Aduhelm, an Alzheimer's drug that was not to be

Judge in Trump's Jan. 6 case gives attorneys 2 weeks to propose trial date

Pope greeted like rockstar, appears revitalized at 'Catholic Woodstock' in Portugal

Vertex non

knowledge

hotspot

hotspot

hotspot