hotspot -WSS

hotspot

author：focus 2025-09-30 01:13:36 - browse：4

Verve Therapeutics CEO Sekar Kathiresan Verve

SAN FRANCISCO — The promise of genome editing has given rise to potentially curative medicines for rare, life-threatening diseases that generally affect small numbers of patients. But since Verve Therapeutics was founded in 2018, it’s had a wider aperture: using the molecular tools of genome editing to go after the most common cause of death in the world.

The plan, according to Verve CEO Sekar Kathiresan, is to edit out heart attacks for the millions of people at risk for severe cardiovascular disease. It’s a goal that’s more than a little audacious. There’s just one approved genome editing medicine, a treatment for sickle cell disease, and it only passed Food and Drug Administration review last month. Base editing, the CRISPR successor Verve uses to conduct its molecular surgery, is only a few years old.

“When we started, there were so many things that we were kind of going against the grain on,” Kathiresan told STAT at the J.P. Morgan Healthcare Conference in San Francisco this week. “In 2018, it was all about platforms, not about specific diseases and products, or taking this kind of idea for a large indication as opposed to cancer or rare disease. But we’ve always been motivated by a deep conviction in one simple research insight, which is that if your blood cholesterol is really low, lifelong, it is very hard to get a heart attack.”

Get unlimited access to award-winning journalism and exclusive events.

Subscribe Log In

Previous article： In Memoriam: Notable people who died in 2023
Next article： Medical students need to learn the potent medicine of empathy

hotspot

WSS

Unmasking the 'centricity' illusion in clinical trials

STAT Virtual Event: ASCO Recap, Live!

Statins may not be needed by millions of people, study suggests

New report analyzes digital physical therapy solutions' effectiveness

Achieving telehealth equity for people with hearing loss

Some medical students still think black patients feel less pain

entertainment

hotspot

focus

Virginia high school admissions case could be legal follow

How faith leaders like me can help address America's obesity epidemic

In Memoriam: Notable people who died in 2023

Beyond aggravation: Constipation is an American epidemic

Food as medicine: CMS rules hamper 'prescribing' of fruits, veggies

New report analyzes digital physical therapy solutions' effectiveness

Bright Health sells Medicare Advantage business to Molina

Coercive sterilizations revealed by STAT prompt outrage

How one medical school became remarkably diverse

Richard Slayman had a rejection episode of his pig kidney before leaving hospital

hotspot

Report captures long Covid’s disabling effects and policy challenges

Cancer thrives by mutating. But sometimes, a mutation leaves it vulnerable

Coercive sterilizations revealed by STAT prompt outrage

Health care court cases: Humana, Sutter, Novant

The world needs the new pandemic treaty

Cancer thrives by mutating. But sometimes, a mutation leaves it vulnerable

Wikipedia

hotspot

hotspot

hotspot