comprehensive -WSS

comprehensive

author：comprehensive 2025-09-29 13:31:00 - browse：143

Alzheimer’s disease has killed at least three women in Astrida Schaeffer’s family over two generations, leaving her feeling helpless and bereft.

The first was her Polish-born maternal grandmother, who began showing symptoms when Schaeffer started college in 1981 and died seven years later. Then came her mother, a onetime Fulbright Scholar and high school language teacher who had been fluent in five languages but lost the ability to speak. She died in 2019. Last year, the disease killed Schaeffer’s mother’s sister, a former lab technician for Johnson & Johnson.

Schaeffer, a 59-year-old costume historian in North Berwick, Maine, has no symptoms of Alzheimer’s. But in 2021 her family history led her to apply to join a clinical trial testing a drug on people at risk for developing them. To participate, volunteers couldn’t have cognitive impairment. But they needed to test positive for a biomarker that put them at higher risk for mental decline ― deposits of a sticky toxic protein in the brain called beta-amyloid that is a hallmark of the disease.

Get unlimited access to award-winning journalism and exclusive events.

Subscribe Log In

Previous article： At least 13 dead in Texas as scorching temps continue
Next article： FTX founder Sam Bankman

explore

WSS

R1 RCM gets $5.8 billion buyout offer from private equity firm

Mega Millions jackpot estimated at record $1.58 billion for Tuesday's drawing

Trump attorney outlines possible Jan. 6 legal defenses, but some experts are skeptical

With competition flaring, obesity drug hits goal in liver disease study

Wegovy cuts risk of cardiovascular events by 20%, study finds

Travel bans should be based on evidence, not politics or fear

explore

comprehensive

focus

Psychedelics group wrestles with new pharma identity

PBM reform efforts get punted in Congress

Anesthesiologist group: stop taking Ozempic before surgery

With competition flaring, obesity drug hits goal in liver disease study

New air purifier tech could be key to improving indoor air quality

The Readout: Abbvie and Humira, CRISPR in utero, Annovis Bio

Medical leaders decry Supreme Court decision on affirmative action

Astronauts get first look at the spacecraft that will fly them around the moon

What does generative AI mean for health care? We asked experts

The painfully weak evidence on taking collagen to treat arthritis

Wikipedia

Judge rejects Trump's counterclaim against E. Jean Carroll

Zapping the brain for stroke rehab: Pivotal clinical trial begins

Obesity drugs seen as possible treatment for liver disease MASH

Readout Newsletter: Alnylam, Celldex, Roche, Zealand Pharma

In venture capital firm's success, lessons for turning crisis into profit

‘The Bear’ and hospitality in hospitals

explore

knowledge

focus

hotspot