explore -WSS

explore

author：leisure time 2025-09-28 18:20:41 - browse：556

Scientist pipetting in a biotech lab -- biotech coverage from STAT — A researcher working in the lab at Crinetics Pharmaceuticals in San Diego. Courtesy Crinetics

SAN DIEGO — Crinetics Pharmaceuticals announced on Sunday that its experimental drug for acromegaly, a rare and serious hormonal disorder, succeeded in a late-stage trial, bringing the San Diego biotech a step closer to applying for Food and Drug Administration approval — and entry into a crowded market with blockbuster therapies sold by pharma giants.

In the Phase 3 study, dubbed PATHFNDR-1, nearly 60 patients were randomly assigned to receive a placebo or a daily dose of paltusotine, an oral medicine designed to lower levels of growth hormone, which is produced in excess by people with acromegaly. After 36 weeks of treatment, 25 of the 30 patients given the drug had growth-factor levels that were within the normal range compared to just 1 of 28 participants who took the placebo, a difference that was statistically significant. Researchers also found that the treatment’s side effects were mild overall.

Crinetics plans to file for FDA approval if it gets positive results from a second, ongoing Phase 3 trial of the drug in acromegaly patients. The biotech expects results from that study, known as PATHFNDR-2, by the first quarter of next year.

Get unlimited access to award-winning journalism and exclusive events.

Subscribe Log In

Previous article： Heart attack and stroke risk calculators need revising
Next article： Sage hopes for a blockbuster in antidepressant now before FDA

leisure time

WSS

Tire on Delta flight pops while landing in Atlanta, 1 person injured, airline says

Mitch McConnell episode has important public health takeaway

Congress must protect the remaining independent doctors

AMAs digital advisors table RPM coding reform proposal, again

Eli Lilly reports tirzepatide MASH success during Q4 earnings

Report cites 'urgent' need to recruit more diverse clinical trial participants

entertainment

explore

Wikipedia

What does generative AI mean for health care? We asked experts

Canadian Prime Minister Justin Trudeau separating from wife, Sophie

Malaria cases in Florida and Texas: Here’s what you need to know

ACIP vaccine advisory panel sees its vacancies filled

Hollywood unions extend contract negotiations for actors

5 important ways Henrietta Lacks changed medical science

United colonoscopy coverage change 'may cost lives,' doctors say

Lilly to acquire Dermira for $1.1 billion, adding eczema drug to its pipeline

Indiana Supreme Court upholds abortion ban, says state constitution gives only limited protections

Resistance to opioid

explore

STAT Boddities: What happens to the brain when we get scared?

Ebola vaccine can save some who are already sick, per new study

Canadian Prime Minister Justin Trudeau separating from wife, Sophie

Tire on Delta flight pops while landing in Atlanta, 1 person injured, airline says

Tome Biosciences co

Tome Biosciences co

leisure time

focus

focus

focus