Wikipedia -WSS

Wikipedia

author：focus 2025-10-02 00:51:57 - browse：13335

The bacterium A. baylyi was engineered to detect a common cancer mutation. Courtesy of Josephine Wright

Dan Worthley, a gastroenterologist and cancer scientist at Colonoscopy Clinic in Brisbane, Australia, does thousands of colonoscopies a year, seeking and destroying precancerous polyps. It’s a practically surefire way to prevent colorectal cancer, but an unpleasant experience for patients. The future, Worthley hopes, will be much less onerous — and he’s developing a technology that, if it works one day, might make the experience more of a piece of cake.

Or, rather, a cup of yogurt — containing engineered bacteria that can detect and deliver a treatment for colorectal polyps or cancer. Worthley and colleagues at the University of California, San Diego, and the University of Adelaide published results in Science on Thursday that show they are one step closer to that far-off dream. In their paper, the researchers show a proof-of-concept engineered bacterium that can detect cancer DNA in the guts of mice and react to it by turning on certain cellular circuitry.

“I think it’s really cool. It introduces a new concept for how you can use cells as a sensor for something happening inside other cells,” said Mikhail Shapiro, a chemical and medical engineer at the California Institute of Technology who did not work on the study. “That can flip a switch inside those cells. In this case, it’s used for diagnostic output, but in principle it could be used for other things.”

Unlock this article by subscribing to STAT+ and enjoy your first 30 days free!

GET STARTED Log In

Previous article： Duchenne breakthrough therapy leaves behind pioneering families
Next article： Maisha Meds is a PBM, but don't call it that

WSS

NYU Langone launches private ChatGPT for its health care data

Neuroscience startup Neumora files for IPO

Medicare explains how it will choose drugs for negotiation

Appeals court upholds limits to abortion pill

Complete sequence of Y chromosome published for first time

Winners, losers from Medicare’s list of drugs subject to price talks

focus

Wikipedia

explore

Food as medicine: CMS rules hamper 'prescribing' of fruits, veggies

How a symptom of dementia informs our understanding of creativity

In age of alternative facts, a scholarly course on calling out crap

Neuroscience startup Neumora files for IPO

Sports medicine is finally prioritizing gender equality

In science, is the line between industry and academia shifting?

Supreme Court strikes down use of affirmative action

Readout Newsletter: Parkinson's study, Gilead, CG Oncology

United colonoscopy coverage change 'may cost lives,' doctors say

Departing Stanford president retracts two papers

hotspot

Pumping milk in bathrooms at health conferences is common

Medicare explains how it will choose drugs for negotiation

HPV vaccine, cervical cancer study delivers historic results

FDA panel gives mixed vote on blood pressure devices

Dog Aging Project founders on what lies ahead after losing funding

Medicare drug price lawsuits could be good politics for Biden

explore

focus

focus

entertainment