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                                      author：knowledge   
                                        
                                      
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browse：24
                                  
                                    
          
                                    
            
          
 
          ADAM FEUERSTEIN/STAT
          CHICAGO — Corbus Pharmaceuticals is the second best-performing biotech stock this year, thanks to investor interest in an antibody-drug conjugate candidate, or ADC, called CRB-701 with the potential to be better tolerated than Padcev, an ADC treatment bladder cancer that Pfizer acquired as part of its $43 billion Seagen deal.
          On Saturday, Corbus updated results from an early, dose-finding study of CRB-701, showing an overall response rate of 28% from 25 evaluable patients. Closer attention is being paid to the subset of 15 patients treated at three therapeutically active doses, where the overall response rate (all partial tumor shrinkage) was 40%. All of the responses were seen in bladder cancer (where Padcev is approved) and in cervical cancer.
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          The data, from a study conducted in China, were presented in a poster session at the annual meeting of the American Society of Clinical Oncology.
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