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          explore  
          
                                   
                 
                                      author：explore   
                                        
                                      
                                      -
 
browse：4835
                                  
                                    
          
                                    
            
          
 
          Nasdaq
          Mark Lennihan/AP
          The biotech company Acelyrin, which raised more than $500 million in an IPO this year, ran into its first major setback Monday as its investigational anti-inflammatory drug missed the primary goal in a pivotal clinical trial.
          Acelyrin’s medicine, a subcutaneous treatment called izokibep, is meant to clear up lesions for patients with the common skin disease hidradenitis suppurativa, or HS, an inflammatory disorder that leads to abscesses and scars. But after 16 weeks of treatment, patients who received izokibep did not show significant improvements compared to those taking a placebo, failing the study’s primary endpoint.
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          Acelyrin’s share price fell more than 60% in after-hours trading Monday.
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