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          comprehensive  
          
                                   
                 
                                      author：focus   
                                        
                                      
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          Under a microscope, human prostate cancer cells, colorized in blue, appear in an air bubble — coverage from STAT
          Under a microscope, human prostate cancer cells, colorized in blue, appear in an air bubble.																									Adobe
          An early-stage clinical trial of a radiopharmaceutical drug developed by Johnson & Johnson showed some signs of efficacy in prostate cancer patients, newly released data show, but four participants in the trial died.
          The drug, JNJ-6420, is designed to treat metastatic castration-resistant prostate cancer by delivering radioactive isotopes directly to cancer cells. Interest in such radiopharmaceuticals has skyrocketed following the approval of Pluvicto, which also treats prostate cancer.
          advertisement
          In the Phase 1 data reported ahead of the American Society of Clinical Oncology meeting next week, 18% of participants on a mid-level dose of Johnson & Johnson’s treatment had a complete or partial response. For comparison, approximately 29.8% of the subjects in a Phase 3 trial of Pluvicto responded to the treatment.
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          Unlock this article — plus daily coverage and analysis of the biotech sector — by subscribing to STAT+.
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