knowledge -WSS

knowledge

author：comprehensive 2025-09-30 21:57:42 - browse：6

Alnylam headquarters — Kristoffer Tripplaar/Sipa USA/AP

The Food and Drug Administration rejected an Alnylam Pharmaceuticals’ therapy for an increasingly prevalent heart disease, the company said Monday, citing insufficient evidence that the treatment meaningfully improved patients’ lives.

Alnylam will no longer seek approval of its drug, an intravenous medicine sold as Onpattro, for people with ATTR-CM, a progressive disease that leads to heart failure if left untreated. The company is in the late stages of development of an updated version of Onpattro that can be administered through a small needle under the skin. Data from a pivotal study, expected next year, would support an FDA application for that treatment.

For Onpattro, a 12-month clinical trial found that the treatment outperformed placebo on a test of how far patients could walk over the course of six minutes, suggesting the medicine slowed down the progression of ATTR-CM. Onpattro also improved patients’ scores on a quality-of-life questionnaire compared to placebo.

Get unlimited access to award-winning journalism and exclusive events.

Subscribe Log In

Previous article： Hepatitis C has a cure — but many Americans still lack access to it
Next article： Who gets to use the title 'doctor'?

entertainment

WSS

Why ADHD is under

Study: Pain burden is higher in Black NFL players than white ones

How the political right came to back psychedelics to treat trauma

Medicare eyes cuts to doctors, raises to outpatient clinics in 2024

Argenx drug significantly slows progression of nerve disorder

Why police arrested suspected Gilgo Beach killer away from his house

focus

knowledge

hotspot

Virginia high school admissions case could be legal follow

DOJ reversal could clear way for Carroll's 1st lawsuit against Trump to proceed

Over 800 arrested across France in 3rd night of riots after fatal police shooting of teen

Care demand spikes challenge UnitedHealth’s provider arm

Tori Bowie and the unacceptable rates of Black maternal death

California’s proposed $25 per hour health care minimum wage

The cancer drug shortage isn’t new — and neither are the solutions

Special counsel informs Trump he is target in probe of efforts to overturn 2020 election

Anesthesiologist group: stop taking Ozempic before surgery

Congress likely to miss an opportunity to fix drug shortages issue

leisure time

Study: Pain burden is higher in Black NFL players than white ones

Charles Manson follower Leslie Van Houten released from prison after 53 years

Can CDC director Mandy Cohen drive consensus in Washington?

NIH fellows want a pay raise. Will that mean less money for grants?

Petition to FDA: Get the lead out of consumer hair dyes

Congress: Eradicate hepatitis C and reduce the deficit

Wikipedia

entertainment

explore

hotspot