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BIO is proceeding with a restructuring after its new CEO took over. Lane Turner/The Boston Globe

WASHINGTON — The Biotechnology Innovation Organization on Monday is announcing a significant restructuring accompanied by a shakeup, according to five sources familiar with the planning.

A few senior leaders are expected to depart as part of the reorganization. Chief Science Officer Cartier Esham, Chief Public Affairs and Marketing Officer Rich Masters, and Chief Policy Officer John Murphy are expected to leave, four sources said.

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