entertainment -WSS

entertainment

author：hotspot 2025-09-27 22:57:11 - browse：645

A caretaker speaks with an elderly Alzheimer's patient at a nursing home. — ALAIN JOCARD/AFP via Getty Images

For more than 30 years, Alzheimer’s researchers have thought of APOE4 as a major genetic risk factor for most cases of the devastating neurologic disease. But a new study published on Monday argues that this gene variant plays an even more important role than scientists had realized and causes a distinct form of Alzheimer’s.

Researchers analyzed data from more than 13,000 people, including nearly 800 APOE4 homozygotes, people who carry two copies of the gene variant. They found that nearly all of the homozygotes showed biological signs of Alzheimer’s in the brain, and they typically developed dementia and other symptoms, and died sooner, than people with Alzheimer’s who lack APOE4.

The research team also found that APOE4 homozygotes showed a predictable pattern of biomarker changes linked to Alzheimer’s, including a buildup of beta-amyloid and tau, a protein linked to neuron damage and death.

STAT+ Exclusive Story

Already have an account? Log in

This article is exclusive to STAT+ subscribers

Unlock this article — plus in-depth analysis, newsletters, premium events, and networking platform access.

Already have an account? Log in

Monthly

$39

Totals $468 per year

$39/month Get Started

Totals $468 per year

Starter

$30

for 3 months, then $39/month

$30 for 3 months Get Started

Then $39/month

Annual

$399

Save 15%

$399/year Get Started

Save 15%

11+ Users

Custom

Savings start at 25%!

Request A Quote Request A Quote

Savings start at 25%!

2-10 Users

$300

Annually per user

$300/year Get Started

$300 Annually per user

View All Plans

Get unlimited access to award-winning journalism and exclusive events.

Subscribe Log In

Previous article： The high cost of giving birth even with insurance
Next article： WHO recommends dropping component of many flu vaccines

WSS

FDA advisers vote against ALS treatment from BrainStorm

Smaller biotechs seek to piggyback on weight loss drug boom

STAT Summit: How researchers deal with rejection

Researchers use wearables data and AI to predict preterm birth risk

Roivant's CEO is a star, but biotech's black hole persists

Why do women spend more than men on medical expenses?

explore

entertainment

This article is exclusive to STAT+ subscribers

Unlock this article — plus in-depth analysis, newsletters, premium events, and networking platform access.

hotspot

Walensky prepares to leave CDC — and Congress — behind

STAT Readout: Friday, Oct. 20 biotech updates

Cancer drug shortages should be causing more outrage

Why do women spend more than men on medical expenses?

Guidelines to prevent youth baseball injuries need more muscle

Why a market frenzy over new weight loss drugs defies logic

As demand for Covid shots wanes, Moderna seeks its next success

How one patient went off dialysis — and others can too

Trump demands the U.S. pay no more for drugs than other countries … again

STAT Readout: Friday, Oct. 20 biotech updates

explore

Shingles, which affected Dianne Feinstein, is on the rise

STAT Summit: Doctor v. ChatGPT showed AI's promise, blind spots

Data show record exodus of life scientists from academia

How the Dana

Medicare drug price negotiation program allowed for now

Kaiser Permanente unions announce official strike date

knowledge

entertainment

focus

leisure time