knowledge -WSS

knowledge

author：fashion 2025-09-27 12:43:10 - browse：2

On Tuesday, Google DeepMind and Isomorphic Labs announced a significant progress update on the next iteration of AlphaFold, the deep learning model that in 2020 cracked the problem of predicting a protein’s structure from its amino acid sequence, leapfrogging other approaches in computational biology.

Now, the companies say they have developed the model to predict not just standalone protein structures, but what proteins look like in combination with several classes of molecules, including small molecules and nucleic acids — capabilities that are key for drug development.

“We really needed to make progress on protein-ligand binding and co-folding of ligands with proteins in order to help us design more effective drugs,” said Demis Hassabis, CEO of both DeepMind and Isomorphic Labs, which spun out in 2021 with the goal of applying deep learning approaches to drug discovery. The updated model can also predict protein structures after they’ve been modified. “Basically the new AlphaFold can cope with all of these different things, which is pretty amazing.”

Get unlimited access to award-winning journalism and exclusive events.

Subscribe Log In

Previous article： As demand for Covid shots wanes, Moderna seeks its next success
Next article： Despite FDA concern, risk that CAR

WSS

Will the market for weight loss drugs really reach $100 billion?

MD Anderson's Padmanee Sharma responds to research credit suit

Readout Newsletter: The latest in Pfizer, Moderna, and Sanofi

AbbVie CEO Gonzalez to step down after a decade fiercely defending Humira

Surprise medical billing ban raises prices elsewhere

The EPA's new lead rule: How one expert crunched the numbers

hotspot

knowledge

explore

The cancer drug shortage isn’t new — and neither are the solutions

Readout LOUD podcast: Pharma in Washington, Alnylam, and Gilead

Malaria cases in Florida and Texas: Here’s what you need to know

Measles policy set amid Florida outbreak alarms vaccine proponents

How one medical school became remarkably diverse

Opioid cravings were reduced by anti

Bright Health sells Medicare Advantage business to Molina

Takeda, Janssen join wearable maker to measure scratching

New Eli Lilly Alzheimer’s data poses Medicare coverage conundrum

FDA investigates CAR

leisure time

The EPA's new lead rule: How one expert crunched the numbers

A new drug could help frostbite victims avoid its ravages

Saudi VC loops Novo Nordisk, biotech VCs into longevity incubator

CDC director unscathed in first congressional testimony

Organ aging and disease risk measured by new blood test

Despite FDA concern, risk that CAR

Wikipedia

knowledge

knowledge

hotspot