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          comprehensive  
          
                                   
                 
                                      author：knowledge   
                                        
                                      
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browse：558
                                  
                                    
          
                                    
            
          
 
          Peter Marks. -- health coverage from STAT
          Peter Marks, Director of the Center for Biologics Evaluation and Research at the Food and Drug Administration.																									Susan Walsh-Pool/Getty Images
          Peter Marks wants drug developers to ask more stupid questions.
          It’s part of the top Food and Drug Administration official’s plan to reinvigorate gene therapy, a field that has struggled despite significant technological advances. Some companies are shelving programs or going out of business, even when they have promising data. 
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          The problems are numerous: The diseases are often exceptionally rare, limiting the potential market. Manufacturing at commercial quality is complex and expensive. Proving a drug works can be difficult, because there may be too few patients to run a traditional randomized study. 
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