knowledge -WSS

knowledge

author：leisure time 2025-09-06 04:14:34 - browse：723

Ionis Pharmaceuticals, a California biotech that has spearheaded the development of RNA-targeting medicines, announced on Tuesday that its drug against familial chylomicronemia syndrome, a rare and serious disease that prevents the body from breaking down fats, succeeded in a late-stage clinical trial.

The Phase 3 trial, dubbed Balance, enrolled 66 adults who were randomly divided into three groups and given a monthly injection of placebo or one of two doses of olezarsen, the company’s experimental drug. Treatment with the higher dose of the therapy significantly lowered triglycerides in the blood of those on the drug for six months compared to participants given placebo, though a lower dose did not have this effect. Participants on the high dose didn’t have any instances of painful inflammation of the pancreas, one of the disease’s most serious symptoms, while there were 11 such episodes among those on placebo.

Researchers reported that the treatment was also generally safe, with fewer adverse events among those on olezarsen than among the placebo group.

Get unlimited access to award-winning journalism and exclusive events.

Subscribe Log In

Previous article： Food as medicine: CMS rules hamper 'prescribing' of fruits, veggies
Next article： Genentech weighs delaying cancer therapy after drug pricing law

Wikipedia

WSS

After John Oliver segment, STAT readers share their opioid

CDC overhauls leadership of center that led response to Covid

Create a giant ice tray with this foil pan hack to keep food cold this summer

Create a giant ice tray with this foil pan hack to keep food cold this summer

Dozens of beaches across Northeast closed for swimming due to high levels of bacteria in water

See Ryan Reynolds, Hugh Jackman suited up in 1st look at 'Deadpool 3': Photo

hotspot

knowledge

hotspot

Heart attack and stroke risk calculators need revising

Newly revealed memo details efforts to keep Trump in power following election loss

Biden outlines 'new path' to provide student loan relief after Supreme Court rejection

Iran moves toward freeing 5 American citizens who had been imprisoned, in rare deal

New air purifier tech could be key to improving indoor air quality

After John Oliver segment, STAT readers share their opioid

Medical leaders decry Supreme Court decision on affirmative action

Rikers Island jail violence not addressed, NYC should be held in contempt: Fed monitor

Hepatitis C has a cure — but many Americans still lack access to it

Giraffe named Twiga, who was among the oldest cared for by humans, died at age 31 at East Texas zoo

focus

Newly revealed memo details efforts to keep Trump in power following election loss

Home health providers sue Medicare over payment cuts

ACA's risk program benefits Blue Cross Blue Shield insurers

GOP presidential candidates start declaring their loyalty

Biden targets hefty hospital 'facility fees' that often surprise patients

Bank of America ordered to pay more than $100 million for double charging fees, withholding rewards

hotspot

focus

Wikipedia

explore