explore -WSS

explore

author：knowledge 2025-09-04 22:02:41 - browse：85

LONDON — An experimental blood cancer drug from MorphoSys hit its primary target in a pivotal trial, the company announced late Monday, but the drug faltered in addressing patient symptoms, causing the company’s stock to fall in early Tuesday trading.

In the Phase 3 trial, the German company was testing its drug candidate pelabresib combined with the drug Jakafi against a Jakafi-placebo duo in patients with newly diagnosed myelofibrosis, a type of rare blood cancer. Jakafi is a standard myelofibrosis treatment.

The drug combination succeeded on its primary endpoint, with 66% of patients seeing at least a 35% reduction in spleen volume after 24 weeks versus 35% on the placebo regimen — an improvement the company in a release called “statistically significant and clinically meaningful.” Myelofibrosis is a rare bone marrow cancer that causes low blood cell counts and enlarged spleens, so reducing spleen volume is commonly used as the primary efficacy goal in clinical trials.

Get unlimited access to award-winning journalism and exclusive events.

Subscribe Log In

Previous article： Anesthesiologist group: stop taking Ozempic before surgery
Next article： Maui's cultural, historic landmarks damaged in the devastating wildfires

hotspot

WSS

Jack Smith previously got search warrant for Trump's Twitter, new court docs show

The best solution to the drug shortages problem

Aspartame and sugar

Surge in Apellis stock fueled by confidence in safety of its eye drug

After Optum profits sink, UnitedHealth makes changes

South Korea throws huge K

hotspot

explore

focus

The cancer drug shortage isn’t new — and neither are the solutions

Patients, digital health players weigh in on FTC's data privacy plan

Apple is now the first public company to be valued at $3 trillion

Aspartame and sugar

Cancer drug shortages should be causing more outrage

After Optum profits sink, UnitedHealth makes changes

The Supreme Court will review a ruling striking down a domestic violence federal gun ban

Mark Cuban is blaming the wrong people for high drug costs

Over 800 arrested across France in 3rd night of riots after fatal police shooting of teen

Illumina slashes 2023 revenue projections yet again

entertainment

Twitch streamer Kai Cenat speaks out for 1st time since causing mayhem with Union Square giveaway

NIH trials fail to test meaningful long Covid therapies, experts say

NIH trials fail to test meaningful long Covid therapies, experts say

BMS, looking to build heart drug business, turns to AI for diagnosis

Q&A: Figuring out how songbirds sing may lead to better understanding of how humans learn

Biogen’s boardroom scandal saddles CEO with first crisis

hotspot

Wikipedia

hotspot

Wikipedia