knowledge -WSS

knowledge

author：knowledge 2025-09-05 06:04:20 - browse：41239

On Tuesday, Google DeepMind and Isomorphic Labs announced a significant progress update on the next iteration of AlphaFold, the deep learning model that in 2020 cracked the problem of predicting a protein’s structure from its amino acid sequence, leapfrogging other approaches in computational biology.

Now, the companies say they have developed the model to predict not just standalone protein structures, but what proteins look like in combination with several classes of molecules, including small molecules and nucleic acids — capabilities that are key for drug development.

“We really needed to make progress on protein-ligand binding and co-folding of ligands with proteins in order to help us design more effective drugs,” said Demis Hassabis, CEO of both DeepMind and Isomorphic Labs, which spun out in 2021 with the goal of applying deep learning approaches to drug discovery. The updated model can also predict protein structures after they’ve been modified. “Basically the new AlphaFold can cope with all of these different things, which is pretty amazing.”

Get unlimited access to award-winning journalism and exclusive events.

Subscribe Log In

Previous article： Medical records are filled with copy
Next article： Snackable artificial intelligence, expert AI, and the pharma industry

knowledge

WSS

Crinetics acromegaly drug succeeds in late

NIH nominee Bertagnolli will get October confirmation hearing

What we’ve learned from the Aduhelm mess

'Revelatory' study finds a smoking impact that remains after quitting

House transparency, PBM reform bill gains bipartisan support

Gilead acquiring CymaBay and its liver disease drug for $4.3 billion

leisure time

knowledge

entertainment

Trump demands the U.S. pay no more for drugs than other countries … again

Medicare Advantage proposed rates disappoint insurers

Tori Bowie and the unacceptable rates of Black maternal death

Biogen Alzheimer’s drug launch off to slow start

Apple is now the first public company to be valued at $3 trillion

The (many) problems with a new study criticizing cancer screening

The Supreme Court will review a ruling striking down a domestic violence federal gun ban

Biden report: The neurospychology of memory and aging

Biden outlines 'new path' to provide student loan relief after Supreme Court rejection

To avoid data mishandling cases, universities eye AI and other tools

entertainment

Crinetics acromegaly drug succeeds in late

Medicaid rebukes states for mistakenly disenrolling children

'Make People Better': The CRISPR babies story you probably don't know

Trump surgeon general acknowledges mistakes during Covid

Gilead might be held responsible for not developing a drug

A ‘polypill’ could sharply reduce cardiovascular disease in the U.S.

knowledge

leisure time

knowledge

hotspot