Wikipedia -WSS

Wikipedia

author：hotspot 2025-08-26 03:42:34 - browse：3198

Adam's take main illustration — Molly Ferguson/STAT

The Food and Drug Administration should halt Cassava Sciences’ ongoing clinical trials in Alzheimer’s disease. That, and other thoughts on the fallout from the City University of New York investigation that raised serious doubts about the science underpinning the company’s experimental drug simufilam.

Patient safety is paramount to the FDA, so stopping Cassava’s two Phase 3 studies is the ethically correct thing to do.The FDA has the power to place clinical holds on experimental drugs when there’s evidence of an unacceptable safety risk to study participants. Simufilam doesn’t appear to be toxic. It’s not causing dangerous side effects. But study participants can also be harmed when they volunteer for a clinical trial based on false or misleading information about a drug’s potential efficacy.

The CUNY committee charged with investigating Cassava’s principal scientific collaborator, the neuroscientist Hoau-Yan Wang, could not definitively prove that Wang faked simufilam data, but that’s only because he refused to turn over original data and primary research records that the committee had requested to examine. Wang also claimed that boxes of research records relevant to the investigation were thrown away. The investigative report was first made public last week in the journal Science.

Get unlimited access to award-winning journalism and exclusive events.

Subscribe Log In

Previous article： Hepatitis C has a cure — but many Americans still lack access to it
Next article： Grail faces three suits alleging harassment, retaliation

hotspot

WSS

Involuntary treatment for addiction doesn't work

Can CDC director Mandy Cohen drive consensus in Washington?

Does aspartame cause cancer? What new WHO guidance says

Readout Newsletter: New research from Sanofi, Regeneron, etc.

FDA has safety concerns on CRISPR

Chimpanzees, like humans and whales, get menopause: Study

Wikipedia

Wikipedia

focus

Bright Health sells Medicare Advantage business to Molina

Traditional Chinese medicine benefits explored in new JAMA study

Indiana Supreme Court upholds abortion ban, says state constitution gives only limited protections

First Opinion Podcast: How to protect health care in times of war

Over 800 arrested across France in 3rd night of riots after fatal police shooting of teen

Senate panel to vote on hospitals, PBMs, prisoner care

The high cost of giving birth even with insurance

Europe sees delivery challenges ahead on Alzheimer's therapies

Guidelines to prevent youth baseball injuries need more muscle

An exit interview with Bristol Myers Squibb CEO Giovanni Caforio

focus

FDA approves Eli Lilly ulcerative colitis treatment Omvoh

Why police arrested suspected Gilgo Beach killer away from his house

J&J expands global access to TB drug amid advocacy campaign

Argenx drug significantly slows progression of nerve disorder

Georgia court denies Trump's request to quash DA's 2020 election probe

Physician subsidies by hospitals soar in wake of No Surprises Act

knowledge

hotspot

hotspot

focus