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Hello, everyone. Damian here with the fallout from Pfizer’s downbeat update, a new entrant in obesity research, and an orthogonal CRISPR business.

The need-to-know this morning

Apellis Pharmaceuticals said a European advisory committee is expected to recommend against the approval of Syfovre, its eye drug for a common form of blindness. The company plans to appeal the negative ruling.
Sage Therapeutics and Biogen announced the commercial launch of Zurzuvae, an oral treatment for women with postpartum depression.
Merck and Moderna reported three-year follow-up data on their mRNA-based immunotherapy for advanced melanoma. Phase 3 studies are underway.
The FDA accepted Amgen’s marketing application for tarlatamab, a bispecific antibody to treat advanced small cell lung cancer. The approval decision date is June 12, 2024.

Is it time to worry about Moderna?

Yesterday’s news that Pfizer is expecting to sell far fewer Covid-19 vaccines than Wall Street expected sent shares of Moderna down as much as 6% on fears that the company could be in for a painful revision of its own.

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Wikipedia

The need-to-know this morning

Is it time to worry about Moderna?

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How to save PrEP access — and even expand it

ASCO eve: Let’s set the table for this year's meeting

ChatGPT in medicine: STAT answers readers' burning questions

Father who lunged at Larry Nassar comforted by deputy who pinned him down: 'I understand'

Sports medicine is finally prioritizing gender equality

Reports of telehealth's death have been greatly exaggerated

After affirmative action ruling, medical educators look to 'holistic review'

Kansas must stop changing trans people's sex listing on driver's licenses, judge says

George Santos makes 1st court appearance after pleading not guilty to 13 counts

Investigation reveals sickle cell patients pressured into sterilizations

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Another man arrested in connection with shooting at Kansas nightclub

ASCO eve: Let’s set the table for this year's meeting

Liver decline slowed by off

Eyeing GLP

Father who lunged at Larry Nassar comforted by deputy who pinned him down: 'I understand'

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